Female steroids side effects

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

Anabolic steroids can cause the development of acne. However, the extent to which it is experienced can be due to a number of varying factors, with the particular steroids and exact dosages used being primary. The skin´s sebaceous glands have a particularly high affinity to Dihydrotestosterone, which is an androgen the body naturally produces from testosterone via the enzyme 5-alpha Reductase. Increased sebaceous gland activity promotes oily skin which can combine with bacteria and dead skin (normal wear and tear) eventually causing pores to become clogged more quickly than the body can cleanse them. This of course, is preventable by using only particular steroids, cleansing the skin regularly, and perhaps using a topical anti-androgen.

In addition to the mentioned side effects several others have been reported. In both males and females acne are frequently reported, as well as hypertrophy of sebaceous glands, increased tallow excretion, hair loss, and alopecia. There is some evidence that anabolic steroid abuse may affect the immune system, leading to a decreased effectiveness of the defense system. Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.

The side effects associated with steroid abuse are particularly negative for women, resulting in a whole range of various problems and unwanted effects including – but not limited to – deepening of the voice, increased body hair and clitoromegaly , or an abnormal enlargement of the clitoris. So take a look at the following professional female body builders and decide for yourself where you think the boundary between beauty/obsession lies and whether or not these people have left that line so far behind that they begin to lose all traces of their femininity. One note: The portraits are done by photographer Martin Schoeller as part of a series of portraits of female bodybuilders, check out some of his work here .

Female steroids side effects

female steroids side effects

The side effects associated with steroid abuse are particularly negative for women, resulting in a whole range of various problems and unwanted effects including – but not limited to – deepening of the voice, increased body hair and clitoromegaly , or an abnormal enlargement of the clitoris. So take a look at the following professional female body builders and decide for yourself where you think the boundary between beauty/obsession lies and whether or not these people have left that line so far behind that they begin to lose all traces of their femininity. One note: The portraits are done by photographer Martin Schoeller as part of a series of portraits of female bodybuilders, check out some of his work here .

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