APS Researchers studied three types of lipid based delivery systems were evaluated for increasing bioaccessibility of Chrysin. With over 10 types of delivery methods studies we found four types of lipid based delivery systems, namely nanoemulsions, gel-like emulsions, Cocrystallization and organogels that proved effective in increasing the bioaccessibility of Chrysin when compared to the dispersion of the compound in water. APS Researchers concluded that less than 1% of the Chrysin was absorbed unchanged in the gastrointestinal tract. This was not surprising given that Chrysin has extremely low water solubility, a major factor in drug absorption. Not only was Chrysin absorbed poorly but also it was conjugated extensively in the liver following oral administration. Our proprietary two stage delivery system was shown to increase the solubility 14-fold. We hypothesized that this improved solubility would translate into enhanced systemic absorption of Chrysin. This hypothesis was supported in our pharmacokinetic study. The outperformed Chrysin with increases in bioavailability up to nearly 10-fold!
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