Psoriasis is a condition that affects the life cycle of skin cells. The condition causes cells to build up rapidly on the skin, causing itchy and dry red patches or thick, silvery scales. Psoriasis can cause pain in the joints, thickened nails and itching, burning or soreness. It is a persistent, long-term condition that comes in many types depending on where it is found in the body and which symptoms it causes. Psoriasis is related to T-cell immune responses that cause the body to attack healthy skin cells. Clobetasol propionate is used to treat mild to moderate psoriasis. It can help suppress the immune system, which gives the body time to heal. The cream is typically used on sensitive areas during outbreaks to help protect delicate areas of the body such as skin folds or the face.
Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) suppression and/or manifestations of Cushing's syndrome in some patients. Clobetasol propionate has been shown to suppress the HPA axis at doses as low as 2 g/day. Conditions which increase systemic absorption include application of high-potency corticosteroids, use over large surface areas, prolonged use, use in areas where the epidermal barrier is disrupted (., skin abrasion), use in pediatric patients, use in patients with hepatic disease, and the use of an occlusive dressing. Clobetasol propionate preparations should not be used with occlusive dressings. Patients receiving large doses of a potent topical corticosteroid like clobetasol should be evaluated periodically for evidence of HPA axis suppression and manifestations of Cushing's syndrome. If these effects are noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation. Infrequently, signs and symptoms of withdrawal may occur, requiring supplemental systemic corticosteroids. It is recommended that the administration of clobetasol creams, ointments, gels, or topical solutions be limited to no more than 14 days duration, in order to limit the risk of systemic effects. Clobetasol propionate emollient creams may be administered for up to 4 weeks duration if applied to no more than 5—10% of body surface area. The total weekly dose limit of 50 g or 50 mL of a % preparation should not be exceeded for any clobetasol preparation.