Flunisolide nasal spray is absorbed into the circulatory system (blood).  Corticosteroid nasal sprays may affect the hypothalamic-pituitary-adrenal axis function in humans.  After the desired clinical effect is obtained, the maintenance dose should be reduced to the smallest amount necessary to control symptoms, which can be as low as 1 spray in each nostril a day. Utilizing the minimum effective dose will reduce possibility of side effects.  Recommended amounts of intranasal corticosteroids are generally not associated with systemic side effects.