Testosterone, like many anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered parenterally in normal and delayed-release (depot) forms. In September 1995, the FDA approved testosterone transdermal patches (Androderm), and many transdermal forms and brands are now available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA-approved in July 2003; Striant is a mucoadhesive product that adheres to the buccal mucosa and provides a controlled and sustained release of testosterone. In May 2014, the FDA approved an intranasal gel formulation of testosterone (Natesto). A transdermal patch (Intrinsa) for hormone replacement in women is under investigation; the daily dosages used in women are much lower than for products used in males. The FDA refused approval for Intrinsa in 2004 stating that more data regarding safety, especially in relation to cardiovascular and breast health, were required.
Parasympathomimetics while the use of testosterone propionate side effects may increase the violation of AV conduction and increase the risk of bradycardia. Simultaneous use of the drug Bisangil beta-agonists (., isoprenaline, dobutamine) may reduce the effects of both drugs. testosterone propionate side effects combination with agonists affecting the beta- and alpha-adrenergic receptors (such as norepinephrine, epinephrine), may enhance the effects of vasoconstrictor agents occurring with alpha adrenergic receptors, resulting in an increase in blood pressure. Such interactions are more likely when using non-selective beta-blockers.
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