Interaction with other drugs
Effect of macrolide antibiotics on parabolan dosage plasma levels when used together has not been studied. Given the possibility of increasing the level of parabolan dosage, the drug is not recommended for use in combination with macrolides.
The mechanism of action of parabolan dosage is associated with the direct stimulation of dopamine receptors, so it should not be used in combination with antagonists of dopamine receptors (phenothiazines, butyrophenones, thioxanthenes, metoclopramide).
No information is available about the interaction parabolan dosage with other ergot alkaloids, however, not recommended for long-term use of such a combination.
Given the pharmacodynamics of parabolan dosage (hypotensive effect), it is necessary to take into account the interaction with drugs that reduce blood pressure.
In clinical studies in patients with Parkinson’s disease pharmacokinetic interaction with levodopa, or selegiline were found. Pharmacokinetic interactions with other drugs on the basis of the available information about the metabolism of parabolan dosage is impossible to predict.
Dopamine is a multi-function neurotransmitter participating in the regulation of mobility, learning, emotions, appetite and positive reinforcing effects. It is an important neurotransmitter for operating the reward system, so dopamine is essential for addiction development. Serotonin, in turn, regulates sleep patterns, movement, appetite, sexuality and emotions. According to some studies, it is also related to memory operations and sustainable concentration.
Among other findings in animal experiments we’ve found that an anabolic steroid, nandrolone, changes the dopamine system response to stimulating intoxicants. The release of intoxicant-induced neurotransmitters lessens, and so does the pleasure procured from using intoxicants. (). In some studies, androgenic compounds have been shown to have direct activating functions for dopamine and serotonin release ().
There is no doubt that many of the physical side effects of steroid misuse and abuse can contribute to emotional and mental side effects and disorders.
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Dangers of Injecting Steroids It’s not just physical and emotional/mental side effects that steroid users have to worry about.